ISB ~ Revelation 18 v4

Come out of her:A call to escape the harlot city before its demise (cf. Gen 19:12-14; Tob 14:4, 8). Some read this as an echo of Jesus’ warning to flee Jerusalem when the time of its judgment draws near (Lk 21:20-21). Others, identifying the city as Rome, read this as a call to escape the godless corruption of the capital, much as Paul emphasizes the moral imperative in a similar prophetic passage (2 Cor 6:17, quoting Is 52:11).

her plagues:The divine curses of the seven seals (6:1-8:5), the seven trumpets (8:6-11:19), and the seven bowls (15:1-16:21).