ISB ~ Revelation 17 v2

fornication:The language of sexual immorality is symbolic of spiritual immorality. In the Bible, acts of harlotry point to transgressions of the covenant, such as idolatry and alliances with godless nations (cf. Ex 34:15-16; Ezek 16:26-29; 23:30; Hos 1:2).

wine:Sins of violence have filled the harlot’s cup with the innocent blood of Christians (17:6).